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Feel Energized Naturally: 9 Immune Supplement Ingredients that are Proven to Improve Fatigue

Feeling exhausted? You’re not alone. Fatigue is one of the most common issues we face in our modern lives – and it’s preventing us from achieving our best health and wellbeing. 

Thankfully, we don’t have to live with overwhelming fatigue forever. Nature provides us with several healing ingredients that improve fatigue and boost both our base energy levels and everyday immune support. Let’s learn why fatigue is such an important issue to overcome and how natural ingredients in an immunity supplement can improve your energy naturally. 

Our Fatigue Epidemic 

You wake up tired and sluggish. You fuel up on caffeine and sugar just to get through the day. You go to bed just as exhausted as you woke up. 

Sound familiar?

Unfortunately, this is a reality that has become far too common in our modern society. Forty-three percent of Americans report feeling too tired to do their daily activities or work properly. Many more suffer from regular bouts of fatigue and sleep deprivation. 

The Institute of Medicine estimates that an additional 2.5 million Americans are struggling with a condition that’s even more complex than just a lack of energy: chronic fatigue syndrome (1). CFS is a multisystem condition in which severe fatigue, cognitive dysfunction, sleep problems, and general malaise impair a person’s ability to live their life fully (2).

How Does Fatigue Impact Our Health?

Whether you struggle with chronic fatigue or simply feel tired on a daily basis, fatigue negatively impacts your physical, mental, and emotional health.  

Fatigue can make even the lightest exercise feel like a marathon. It also impairs your cognitive abilities and could sabotage your focus, productivity, problem-solving, and creativity (3). Fatigue is also linked with mental health struggles like stress, anxiety, depression, or forgetfulness (4). 

Oftentimes, adopting simple lifestyle habits can quickly improve your fatigue: 

  • Make sure you’re getting enough nutrients in your diet. 

  • Stay hydrated during the day

  • Exercise daily 

  • Get 7-9 hours of sleep each night

  • Avoid stressors and engage in stress relief activities

  • Reduce your intake of alcohol, tobacco, sugar, and caffeine

Aside from these general habits, consider boosting your diet with ingredients that raise your energy naturally, like those found in an immune supplement. The following vitamins, minerals, and herbs have been proven through research to fight fatigue and improve your overall health.

9 Energy-Boosting Ingredients that Help with Fatigue

  1. Black Elderberry

  2. Astragalus

  3. Andrographis

  4. Garlic

  5. Spirulina

  6. Vitamin D

  7. Vitamin C

  8. Zinc

  9. Copper: Like vitamin C, copper is needed to fully absorb and use iron from our food. Copper can boost energy levels by supporting proper iron absorption and therefore healthy blood oxygen levels to fight anemia-related fatigue (19). Other studies show that copper is low in those with chronic fatigue syndrome (20).

Enhance Your Energy with Nature

Fatigue can prevent you from living your life to the fullest, but it doesn’t have to be this way. Supplementing with natural ingredients like these can help you overcome fatigue, while also supporting your overall health, wellness, and resilience.

While it’s possible to beat fatigue naturally, always check with your doctor. If you’re suffering from overwhelming fatigue or sleepiness, it’s important to speak with a trusted healthcare provider to rule out any potential health conditions. 

We’re proud to offer natural wellness solutions developed by Dr. Julie Chen, MD’s integrative medicine. Discover the Wisdom in Wellness vitamin capsule that is right for you today. 


  1. Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; Board on the Health of Select Populations; Institute of Medicine. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness. Washington (DC): National Academies Press (US); 2015 Feb 10. Summary. Available from:

  2. Sapra A, Bhandari P. Chronic Fatigue Syndrome. [Updated 2020 Nov 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from:

  3. Thomas, Marie, and Andrew Smith. “An investigation into the cognitive deficits associated with chronic fatigue syndrome.” The open neurology journal vol. 3 13-23. 27 Feb. 2009, doi:10.2174/1874205X00903010013

  4. Harvey, Samuel B et al. “The relationship between fatigue and psychiatric disorders: evidence for the concept of neurasthenia.” Journal of psychosomatic research vol. 66,5 (2009): 445-54. doi:10.1016/j.jpsychores.2008.12.007

  5. Tiralongo, Evelin et al. “Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial.” Nutrients vol. 8,4 182. 24 Mar. 2016, doi:10.3390/nu8040182

  6. Segerstrom, Suzanne C. “Stress, Energy, and Immunity: An Ecological View.” Current directions in psychological science vol. 16,6 (2007): 326-330. doi:10.1111/j.1467-8721.2007.00522.x

  7. Zhang HW, Lin ZX, Xu C, Leung C, Chan LS. Astragalus (a traditional Chinese medicine) for treating chronic kidney disease. Cochrane Database Syst Rev. 2014 Oct 22;(10):CD008369. doi: 10.1002/14651858.CD008369.pub2. PMID: 25335553.

  8. Chen HW, Lin IH, Chen YJ, Chang KH, Wu MH, Su WH, Huang GC, Lai YL. A novel infusible botanically-derived drug, PG2, for cancer-related fatigue: a phase II double-blind, randomized placebo-controlled study. Clin Invest Med. 2012 Feb 1;35(1):E1-11. doi: 10.25011/cim.v35i1.16100. PMID: 22309959.

  9. Yeh, Tzu-Shao et al. “Astragalus membranaceus improves exercise performance and ameliorates exercise-induced fatigue in trained mice.” Molecules (Basel, Switzerland) vol. 19,3 2793-807. 3 Mar. 2014, doi:10.3390/molecules19032793

  10. Bertoglio, J C et al. “Andrographis paniculata decreases fatigue in patients with relapsing-remitting multiple sclerosis: a 12-month double-blind placebo-controlled pilot study.” BMC neurology vol. 16 77. 23 May. 2016, doi:10.1186/s12883-016-0595-2

  11. Morihara N et al. Garlic as an anti-fatigue agent. Mol Nutr Food Res. 2007 Nov;51(11):1329-34. doi: 10.1002/mnfr.200700062. PMID: 17955479.

  12. Morihara, Naoaki et al. (2006). Aged Garlic Extract Ameliorates Physical Fatigue. Biological & pharmaceutical bulletin. 29. 962-6. 10.1248/bpb.29.962.  

  13. Selmi, Carlo et al. “The effects of Spirulina on anemia and immune function in senior citizens.” Cellular & molecular immunology vol. 8,3 (2011): 248-54. doi:10.1038/cmi.2010.76

  14. Roy, Satyajeet et al. “Correction of Low Vitamin D Improves Fatigue: Effect of Correction of Low Vitamin D in Fatigue Study (EViDiF Study).” North American journal of medical sciences vol. 6,8 (2014): 396-402. doi:10.4103/1947-2714.139291

  15. Suh, Sang-Yeon et al. “Intravenous vitamin C administration reduces fatigue in office workers: a double-blind randomized controlled trial.” Nutrition journal vol. 11 7. 20 Jan. 2012, doi:10.1186/1475-2891-11-7

  16. Mao X, Yao G. Effect of vitamin C supplementations on iron deficiency anemia in Chinese children. Biomed Environ Sci. 1992 Jun;5(2):125-9. PMID: 1642785.

  17. Maes M, Mihaylova I, De Ruyter M. Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS. J Affect Disord. 2006 Feb;90(2-3):141-7. doi: 10.1016/j.jad.2005.11.002. Epub 2005 Dec 9. PMID: 16338007.

  18. Ribeiro, Sofia Miranda de Figueiredo et al. “Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer.” Einstein (Sao Paulo, Brazil) vol. 15,1 (2017): 24-28. doi:10.1590/S1679-45082017AO3830

  19. Wazir, Shoaib M, and Ibrahim Ghobrial. “Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy.” Journal of community hospital internal medicine perspectives vol. 7,4 265-268. 19 Sep. 2017, doi:10.1080/20009666.2017.1351289

  20. Maric, Daniela et al. “Multivitamin mineral supplementation in patients with chronic fatigue syndrome.” Medical science monitor: international medical journal of experimental and clinical research vol. 20 47-53. 14 Jan. 2014, doi:10.12659/MSM.889333



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